Despite decades of pharmacologic advances, schizophrenia remains one of the most serious mental disorders, with high relapse and low recovery rates. This session will: 1) Identify the challenges that patients with schizophrenia face at different stages of their illness and to help clinicians select matching treatment options; 2) Determine ways to increase patient engagement and delivery of multimodal, integrated care aiming to balance efficacy and safety of pharmacologic treatments; and 3) Individualize the available maintenance treatment options for patients with schizophrenia, weighing their respective pros and cons using sensible shared decision-making approaches.