“Solving Clinical Challenges” addresses complex conundrums that are faced by Psych Congress attendees in managing their patients with major depression. Dr. Thase will discuss and respond to real cases and real issues from attendees who were surveyed prior to the conference. Challenges that may be covered include: 1) diagnostic nosology, accurate diagnosis, and screening; 2) pharmacologic treatments; 3) side effect management; and 4) non-pharmacologic treatments.