The 60-year-old classification system of the approximately 150 medications utilized for the treatment of psychiatric disorders (antipsychotics, antidepressants, mood stabilizers, sedative-hypnotics, etc.) is being replaced by a neuroscience-based nomenclature. Most clinicians are unaware of this change or its implications. In this session, the rationale and nature of this change will be discussed and its clinical implications will be reviewed. Using clinical vignettes, the application of this system to the pharmacological treatment of different psychiatric disorders will be summarized.